APPLICATIONS · DISEASE AREA · ONCOLOGY

The oncology biomarker detail your programme decisions depend on

Who responds. Who develops toxicity. Which targets are engaged, and at what dose. We measure the immune, inflammatory and tumour signals behind those questions using NULISA, Simoa, MSD and NGS in a single laboratory, with data back in two weeks.

Talk to a scientist

Request a quote

APPLICATIONS · DISEASE AREA · ONCOLOGY

The oncology biomarker detail your programme decisions depend on

Who responds. Who develops toxicity. Which targets are engaged, and at what dose. We measure the immune, inflammatory and tumour signals behind those questions using NULISA, Simoa, MSD and NGS in a single laboratory, with data back in two weeks.

Talk to a scientist

Request a quote

NULISA, Simoa and MSD under one roof

NULISA, Simoa and MSD under one roof

NULISA, Simoa and MSD under one roof

Data in two weeks

Data in two weeks

Data in two weeks

Element AVITI sequencing in-house

Element AVITI sequencing in-house

Element AVITI sequencing in-house

HTA licensed, GCP compliant

HTA licensed, GCP compliant

HTA licensed, GCP compliant

Start with your target list

Send us the analytes, the matrix and the cohort size. We will tell you which platform measures them, where the sensitivity sits for your specific targets rather than for the panel as a whole, and what the study will take. You will have an answer within one working day.

If we are not the right laboratory for your study, we will say so in that first reply.

Send us your target list

WHat we measure

What we measure for oncology programmes

Oncology biomarker work spans a wide sensitivity range, and no single format covers all of it. We run the platforms that do, in the same laboratory, and combine them when a study needs it.

Deep immune profiling

Validated inflammatory endpoints

Ultra-sensitive focused biomarkers

Angiogenesis and vascular biology

Proprietary targets

Genomic and transcriptomic context

The practical detail

Turnaround

Two weeks from sample receipt, confirmed in writing at quote

Quote

Within one working day of receiving your target list

Up to 1,000-fold greater than conventional ELISA.

Femtogram-per-millilitre for many targets.

SR-X performance figures confirmed per assay at scoping

Sample confirmation

Receipt and condition confirmed within two working days, before anything is consumed

Receipt and condition confirmed within two working days, before anything is consumed

Sample volume

NULISAseq needs 25 µL. Ship 35 µL, which is the assay requirement plus roughly 10 µL of dead volume. MSD, Simoa and NGS volumes are assay-dependent and confirmed at scoping

NULISAseq needs 25 µL. Ship 35 µL, which is the assay requirement plus roughly 10 µL of dead volume. MSD, Simoa and NGS volumes are assay-dependent and confirmed at scoping

Matrices

Plasma, serum and CSF as standard. Non-standard matrices scoped for feasibility and developed in-house

Plasma, serum and CSF as standard. Non-standard matrices scoped for feasibility and developed in-house

Cohort size

Dozens to tens of thousands of samples

Dozens to tens of thousands of samples

Deliverables

Normalised data, QC metrics and run documentation. Bioinformatic analysis available

Normalised data, QC metrics and run documentation. Bioinformatic analysis available

Quality framework

HTA licence 12818. GCP-compliant workflows. Aligned to ISO 15189

HTA licence 12818. GCP-compliant workflows. Aligned to ISO 15189

Regulatory status

For research use only. Not for use in diagnostic procedures

Regulatory status

For research use only. Not for use in diagnostic procedures

For research use only. Not for use in diagnostic procedures

why

Choosing the right approach for your question

Modern oncology programmes rarely rest on a single endpoint. The same study may need to establish:

  • who is responding to immunotherapy

  • who is developing cytokine release syndrome

  • whether the intended target is engaged, and at what dose

  • how the tumour microenvironment is changing

  • which patients belong in which arm

  • which pharmacodynamic signals move before the clinical endpoint does

Those questions do not share one analytical answer. Some need multiplex breadth, some need attomolar sensitivity. All need reproducibility, most of them from limited sample volumes.

A typical route through a programme


Broad NULISA profiling identifies candidate immune, inflammatory and tumour-response signals.

The programme narrows to the biomarkers with the strongest biological and study relevance. Selected markers move into MSD or Simoa for focused validation, where reproducibility and cross-study comparability matter. The validated set then supports response prediction, safety monitoring, target engagement or patient stratification.

A signal worth pursuing moves straight into validation, with the same scientific team and the same chain of custody.
Platform selection is agreed at scoping, before you commit samples.

Where we support oncology programmes

Immunotherapy response and safety

Target engagement and pharmacodynamics

Tumour biology and patient selection

Cross-system oncology

  • Immune checkpoint inhibitor biomarker work

  • CAR-T and T-cell engager safety biomarkers

  • Cytokine release syndrome

  • ICANS (immune effector cell-associated neurotoxicity syndrome)

Immunotherapy response and safety

Target engagement and pharmacodynamics

Tumour biology and patient selection

Cross-system oncology

  • Immune checkpoint inhibitor biomarker work

  • CAR-T and T-cell engager safety biomarkers

  • Cytokine release syndrome

  • ICANS (immune effector cell-associated neurotoxicity syndrome)

HOW IT WORKS

How an oncology project runs with us

1. Scoping conversation
With a senior scientist. We define the scientific question, the targets and the study requirements, and tell you if another approach would serve you better.
2. Study design and quote
We agree panel strategy, sample volumes, QC approach and analytical plan, then issue a written quote with a delivery date. Quotes are returned within one working day.
3. Sample receipt
Samples are logged, inspected against the manifest and QC-checked on arrival. You get written confirmation of receipt and condition within two working days, before anything is consumed.
4. Assay delivery
Your assays run on the relevant platforms, with any sequencing on Element AVITI in the same laboratory. Runs include the QC and bridging samples agreed at design stage, so cohort integrity holds across plates.
5. Data delivery
Normalised data with QC metrics and run documentation, two weeks from sample receipt. Standard analysis included, extended bioinformatics available.
6. Follow-on validation
Orthogonal validation or longitudinal extension of the cohort, without moving supplier.

Start with a scoping conversation

THE ALTHEOME DIFFERENCE

Why oncology teams work with us

The full analytical range in one place

Platform advice shaped by your biology

Specialist matrices

Speed as a design principle

Senior scientific oversight

Analysis by the people who ran the assay

Validated multiplex endpoints, ultra-sensitive single-molecule measurement, discovery-scale profiling, custom development and transcriptomics.

Immune work needs more than one of these more often than not.

Talk to a scientist

THE ALTHEOME DIFFERENCE

Why oncology teams work with us

The full analytical range in one place

Platform advice shaped by your biology

Specialist matrices

Speed as a design principle

Senior scientific oversight

Analysis by the people who ran the assay

Validated multiplex endpoints, ultra-sensitive single-molecule measurement, discovery-scale profiling, custom development and transcriptomics.

Immune work needs more than one of these more often than not.

Talk to a scientist

THE ALTHEOME DIFFERENCE

Why oncology teams work with us

The full analytical range in one place

Platform advice shaped by your biology

Specialist matrices

Speed as a design principle

Senior scientific oversight

Analysis by the people who ran the assay

Validated multiplex endpoints, ultra-sensitive single-molecule measurement, discovery-scale profiling, custom development and transcriptomics.

Immune work needs more than one of these more often than not.

Talk to a scientist

Tell us about your programme

Send us your markers, your sampling constraint and your study design, and a senior scientist will tell you which matrix and platform combination fits, including when plasma alone would answer the question.

Talk to a scientist

Request a feasibility pilot

You will hear from us within one working day.

Tell us about your programme

Send us your markers, your sampling constraint and your study design, and a senior scientist will tell you which matrix and platform combination fits, including when plasma alone would answer the question.

Talk to a scientist

Request a feasibility pilot

You will hear from us within one working day.

Related plataforms
Related capabilities
Related research areas
Related disease areas

Still curious? Find answers in our FAQ's.

FAQ page

Related plataforms
Related capabilities
Related research areas
Related disease areas

Still curious? Find answers in our FAQ's.

FAQ page

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